Studies on SF-1902 A2-A5, minor components of SF-1902 (globomycin).

Studies on SF=1902 A2 A5, minor components of SF-1902 (globomycin).

Four members of globomycin, SF-1902 A2, A3, A4a and A4b were newly isolated from the culture of Streptomyces hygroscopicus SF-1902. These minor components shared four amino acids in common and the fifth was either valine or allo-isoleucine. The fatty acid moiety varied from 3-hydroxy-2-methylheptanoic acid in A2 to 3-hydroxy-2-methylundecanoic acids in A4b. The length of alkyl chain greatly aff...

Isolation and structure of SF-1902 A5, a new globomycin analogue.

SF-1902 is a solvent-soluble, neutral antibiotic produced by Streptomyces hygroscopicus SF-19021). It shows antibacterial activity only against Gram-negative bacteria2). HPLC analysis of the sample seemingly homogeneous on TLC (silica gel, chloroform methanol, 5: 1, or acetone benzene, 2: 1) disclosed the presence of several minor components and one major component SF-1902, as shown in Fig. 1. ...

Arne Tiselius, 1902-1971.

Leopold Schenk (1840-1902).

Leopold Schenk attained international fame by his contributions to the science of embryology. The first chair of embryology in any medical school was established for him in the University of Vienna. This article briefly describes his life and his work.

1902 Inherited Deficiency Of

The lymphocyte function-associated 1 (LFA-1), ~ Mac-l, and p150,95 molecules constitute a family of structurally and functionally related, high molecular weight, human leukocyte surface glycoproteins (1). Each molecule contains an a and a 3 subunit noncovalently associated in an al31 structure. The 3 subunits of Mr 95,000 in each of these three molecules are identical. The molecules are disting...